Albendazole as a promising molecule for tumor control
This work evaluated the antitumor effects of albendazole (ABZ) and its relationship with modulation of oxidative stress and induction of DNA damage. The present results showed that ABZ causes oxidative cleavage on calf-thymus DNA suggesting that this ...
www.ncbi.nlm.nih.gov
https://pubmed.ncbi.nlm.nih.gov/20398289/
Potent inhibition of tumoral hypoxia-inducible factor 1alpha by albendazole - PubMed
These results demonstrate for the first time the effects of an acute dose of ABZ in profoundly suppressing both HIF-1alpha and VEGF within the tumor. This dual inhibition may provide additional value in inhibiting angiogenesis and be at least partially eff
pubmed.ncbi.nlm.nih.gov
https://pubmed.ncbi.nlm.nih.gov/33996598/
Repositioning of Antiparasitic Drugs for Tumor Treatment - PubMed
Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows existing and approved clinical drugs to be innovatively repurposed to treat tumors. Based on the similarities between parasitic diseases and cancer, recent studies a
pubmed.ncbi.nlm.nih.gov
https://pubmed.ncbi.nlm.nih.gov/34188451/
Progress in Redirecting Antiparasitic Drugs for Cancer Treatment - PubMed
Drug repurposing is a feasible strategy in developing novel medications. Regarding the cancer field, scientists are continuously making efforts to redirect conventional drugs into cancer treatment. This approach aims at exploring new applications in the ex
pubmed.ncbi.nlm.nih.gov
https://www.mdpi.com/2072-6694/11/9/1284/htm
Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature
Anticancer treatment efficacy is limited by the development of refractory tumor cells characterized by increased expression and activity of mechanisms promoting survival, proliferation, and metastatic spread. The present review summarizes the current liter
www.mdpi.com
https://www.sciencedirect.com/science/article/abs/pii/S0300908422001092
Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells
Albendazole (ABZ) was initially introduced as an anthelmintic, however, many studies have reported with its anticancer effects. We investigated the an…
www.sciencedirect.com
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