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unicircle 2022. 9. 23. 22:25

https://escop.com/interactions/

 

Table of herb-drug interactions based on the monographs of ESCOP - ESCOP

The rational use of herbal medicinal preparations is based on the proof of quality, safety and efficacy. An important topic for health care professionals is the knowledge about interactions between herbal medicinal products (HMPs) and medications with synt

escop.com

2022

Table of herb-drug interactions based on the monographs of ESCOP

Drug (English name)Drug (Latin name)SpeciesInteractions based on clinical dataPublication

Agnus Castus Agni casti fructus Vitex agnus-castus L. No evidence in literature.
Interactions with dopamine agonists, dopamine antagonists, oestrogens and antioestrogens cannot be excluded due to possible dopaminergic and oestrogenic effects.
2003, 2nd ed.
Agrimony Agrimoniae herba Agrimonia eupatoria L. None reported. 2019, Online
Angelica root Angelicae archangelicae radix Angelica archangelica L. (syn. Angelica officinalis Hoffm.) None reported. 2021, Online
Aniseed Anisi fructus Pimpinella anisum L. None reported. 2014, Online
Arnica flower Arnicae flos Arnica montana L. None reported. 2019, Online
Artichoke leaf Cynarae folium Cynara cardunculus L. (syn. Cynara scolymus L.) None reported. 2009, Suppl. 2nd ed.
Barbados Aloes Aloe barbadensis Aloe barbadensis Mill. Hypokalaemia (resulting from long term laxative use) potentiates the action of cardiac glycosides and interacts with antiarrhythmic drugs and with drugs which induce reversion to sinus rhythm (e.g. quinidine).
Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adrenocorticosteroids and liquorice root) may aggravate electrolyte imbalance.
2014, Online
Bearberry leaf Uvae ursi folium Arctostaphylos uva-ursi (L.) Spreng. None reported. 2012, Online
Bilberry fruit Myrtilli fructus Vaccinium myrtillus L. None reported. 2014, Online
Birch leaf Betulae folium Betula pendula Roth, Betula pubescens Ehrh. None reported. 2015, Online
Black Cohosh Cimicifugae rhizoma Actaea racemosa L. (syn. Cimicifuga racemosa (L.) Nutt.) None reported. 2011, Online
Black Currant leaf Ribis nigri folium Ribes nigrum L. None reported. 2017, Online
Black Horehound Ballotae nigrae herba Ballota nigra L. None reported. 2015, Online
Bogbean leaf Menyanthidis trifoliatae folium Menyanthes trifoliata L. None reported.
Due to their structure and low content the coumarins are presumed not to interact with anticoagulants.
2013, Online
Boldo leaf Boldi folium Peumus boldus Molina None reported. 2003, 2nd ed.
Burdock root Arctii radix Arctium lappa L. (syn. Arctium major Gaertn.), Arctium minus (Hill) Bernh., Arctium tomentosum Mill. None reported. 2016, Online
Butcher's Broom Rusci rhizoma Ruscus aculeatus L. None reported. 2017, Online
Calendula flower Calendulae flos Calendula officinalis L. None reported. 2019, Online
Cape Aloes Aloe capensis Aloe ferox Mill. Hypokalaemia (resulting from long term laxative use) potentiates the action of cardiac glycosides and interacts with antiarrhythmic drugs and with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adrenocorticosteroids and liquorice root) may aggravate electrolyte imbalance. 2014, Online
Capsicum Capsici fructus Capsicum annuum L. var. minimum (Mill.) Heiser, Capsicum frutescens L. Not to be applied topically together with other external products (e.g. other rubefacient or pain relieving gels) at the same application site. 2009, Suppl. 2nd ed.
Caraway fruit Carvi fructus Carum carvi L. None reported. 2009, Suppl. 2nd ed.
Caraway oil Carvi aetheroleum Carum carvi L. None reported. 2019, Online
Cascara Rhamni purshianae cortex Rhamnus purshiana DC. (syn. Frangula purshiana (DC) A. Gray) Hypokalaemia (resulting from long term laxative use) potentiates the action of cardiac glycosides and interacts with antiarrhythmic drugs and with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adrenocorticosteroids and liquorice root) may aggravate electrolyte imbalance. 2015, Online
Cat's Claw bark Uncariae tomentosae cortex Uncaria tomentosa (Willd. ex Roem. et Schult.) DC. None reported. 2018, Online
Centaury Centaurii herba Centaurium erythraea Rafn s.l., Centaurium majus Zeltner, Centaurium suffruticosum (Griseb.) Ronniger (syn. Erythraea centaurium Pers.; Centaurium umbellatum Gilib.; Centaurium minus Garsault) None reported. 2016, Online
Centella Centellae asiaticae herba Centella asiatica (L.) Urb. None reported. 2009, Suppl. 2nd ed.
Cinnamon Cinnamomi cortex Cinnamomum verum J. Presl. None reported. 2003, 2nd ed.
Clove oil Caryophylli aetheroleum Syzygium aromaticum (L.) Merrill et L.M. Perry (syn. Eugenia caryophyllus (Spreng.) Bull. et Harr.) None reported. 2014, Online
Cola Colae semen Cola nitida (Vent.) Schott et Endl. (syn. Cola vera K. Schum.), Cola acuminata (P. Beauv.) Schott et Endl. (syn. Sterculia acuminata P. Beauv.) Due to the caffeine content, concomitant intake of caffeine-containing drinks or psycho-analeptic medicines may cause a stronger caffeine effect. 2014, Online
Comfrey root Symphyti radix Symphytum officinale L. None reported in topical use. 2012, Online
Couch Grass rhizome Graminis rhizoma Agropyron repens (L.) P. Beauv. (syn. Elymus repens (L.) Gould) None reported. 2016, Online
Cranberry Vaccinii macrocarpi fructus Vaccinium macrocarpon Aiton, Vaccinium oxycoccus L. A pharmacokinetic interaction between cranberry juice and warfarin is highly unlikely, despite in some cases with excessive cranberry consumption. 2020, Online
Dandelion leaf Taraxaci folium Taraxacum officinale F. H. Wigg. None reported. 2003, 2nd ed.
Dandelion root Taraxaci radix Taraxacum officinale F. H. Wigg. None reported. 2003, 2nd ed.
Devilïs Claw root Harpagophyti radix Harpagophytum procumbens DC., Harpagophytum zeyheri Decne None reported. 2009, Suppl. 2nd ed.
Dog Rose hip Rosae pseudo-fructus Rosa canina L., Rosa pendulina L. None reported. 2009, Suppl. 2nd ed.
Elder flower Sambuci flos Sambucus nigra L. None reported. 2013, Online
Eleutherococcus Eleutherococci radix Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. None reported. 2009, Suppl. 2nd ed.
Equisetum stem Equiseti herba Equisetum arvense L. None reported. 2018, Online
Eucalyptus oil Eucalypti aetheroleum Eucalyptus globulus Labill., Eucalyptus polybractea R.T. Baker, Eucalyptus smithii R.T. Baker None reported. 2003, 2nd ed.
European Goldenrod Solidaginis virgaureae herba Solidago virgaurea L. None reported. 2018, Online
Fennel fruit Foeniculi fructus Foeniculum vulgare Mill. subsp. vulgare var. vulgare; Foeniculum vulgare Mill. subsp. vulgare var. dulce (Mill.) Batt. Trab. None reported. 2019, Online
Fennel oil Foeniculi aetheroleum Foeniculum vulgare Mill. subsp. vulgare var. vulgare None reported. 2019, Online
Fenugreek Trigonellae foenugraeci semen Trigonella foenum-graecum L. No evidence in literature. 2003, 2nd ed.
Feverfew Tanaceti parthenii herba Tanacetum parthenium (L.) Sch. Bip. None reported. 2014, Online
Frangula bark Frangulae cortex Frangula alnus Mill. (syn. Rhamnus frangula L.) Hypokalaemia (resulting from long term laxative use) potentiates the action of cardiac glycosides and interacts with antiarrhythmic drugs and with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adrenocorticosteroids and liquorice root) may aggravate electrolyte imbalance. 2017, Online
Fumitory Fumariae herba Fumaria officinalis L. None reported. 2018, Online
Garlic Allii sativi bulbus Allium sativum L. An increased International Normalized Ratio (INR) has been observed in 2 patients on warfarin and in one patient on fluindione who had used garlic products.
The results of studies with saquinavir and ritonavir in healthy volunteers remain unclear.
2019, Online
Gentian root Gentianae radix Gentiana lutea L. None reported. 2014, Online
Ginger Zingiberis rhizoma Zingiber officinale Roscoe None reported. 2009, Suppl. 2nd ed.
Ginkgo leaf Ginkgo folium Ginkgo biloba L. An interaction with substances that inhibit blood coagulation cannot be excluded. However, no such interactions have been observed in controlled studies. 2003, 2nd ed.
Ginseng Ginseng radix Panax ginseng C. A. Mey May slightly reduce blood glucose levels. Interaction of ginseng with warfarin is possible. 2021, Upcoming Revision
Goldenseal rhizome Hydrastidis rhizoma Hydrastis canadensis L. Investigations in healthy volunteers revealed significant interactions with drugs that are metabolized by cytochrome P450 3A4/5 (e.g. midazolam) and 2D6 (e.g. debrisoquin). 2013, Online
Greater Celandine Chelidonii herba Chelidonium majus L. None reported. 2003, 2nd ed.
Grindelia Grindeliae herba Grindelia robusta Nutt., Grindelia squarrosa Dunal, Grindelia humilis Hook. et Arn., Grindelia camporum Greene None reported. 2015, Online
Guarana seed Paulliniae semen Paullinia cupana Kunth (syn. Paullinia sorbilis Mart.) Due to the caffeine content, concomitant intake of caffeine-containing drinks or psycho-analeptic medicines may cause a stronger caffeine effect. 2009, Suppl. 2nd ed.
Hamamelis bark Hamamelidis cortex Hamamelis virginiana L. None reported. 2012, Online
Hamamelis leaf Hamamelidis folium Hamamelis virginiana L. None reported. 2012, Online
Hamamelis water Hamamelidis aqua Hamamelis virginiana L. None reported. 2012, Online
Hawthorn berries Crataegi fructus Crataegus monogyna Jacq. (Lindm.); Crataegus laevigata (Poir.) DC. (syn. Crataegus oxyacantha auct.), Crataegus pentagyna Waldst. et Kit. ex Willd., Crataegus nigra Waldst. et Kit., Crataegus azarolus L. None reported. 2009, Suppl. 2nd ed.
Hawthorn leaf and flower Crataegi folium cum flore Crataegus monogyna Jacq. (Lindm.); Crataegus laevigata (Poir.) DC. (syn. Crataegus oxyacantha L.) None reported. 2003, 2nd ed.
Helichrysi flos Sandy everlasting flower Helichrysum arenarium (L.) Moench. None reported. 2019, Online
Hop strobile Lupuli flos Humulus lupulus L. None reported. 2003, 2nd ed.
Horse Chestnut seed Hippocastani semen Aesculus hippocastanum L. None reported. 2003, 2nd ed.
Iceland Moss Lichen islandicus Cetraria islandica (L.) Ach. s.l. None reported. 2003, 2nd ed.
Indian Frankincense Olibanum indicum Boswellia serrata Roxb. ex Colebr. None reported. 2009, Suppl. 2nd ed.
Ispaghula husk Plantaginis ovatae testa Plantago ovata Forssk. (syn. Plantago ispaghula Roxb.) Enteral absorption of concomitantly administered minerals (e.g. calcium, iron, lithium, zinc), vitamins (B12), cardiac glycosides and coumarin derivatives may be delayed. For this reason, other medications should be taken at least 30-60 minutes before ispaghula husk. In the case of insulin-dependent diabetics it may be necessary to reduce the insulin dose. 2016, Online
Ispaghula seed Plantaginis ovatae semen Plantago ovata Forssk. (syn. Plantago ispaghula Roxb.) Enteral absorption of concomitantly administered minerals (e.g. calcium, iron, lithium, zinc), vitamins (B12), cardiac glycosides and coumarin derivatives may be delayed. For this reason, other medications should be taken at least 30-60 minutes before ispaghula husk. In the case of insulin-dependent diabetics it may be necessary to reduce the insulin dose. 2020, online
Ivy leaf Hederae helicis folium Hedera helix L. None reported. 2003, 2nd ed.
Java tea Orthosiphonis folium Orthosiphon aristatus (Blume) Miq. var. aristatus (syn. Ortosiphon stamineus Benth.) None reported. 2014, Online
Javanese Turmeric Curcumae zanthorrhizae rhizoma Curcuma zanthorrhiza Roxb. None reported. 2009, Suppl. 2nd ed.
Juniper Juniperi galbulus Juniperus communis L. None reported. 2003, 2nd ed.
Kava-Kava Piperis methistici rhizoma Piper methisticum G. Forst None confirmed. 2003, 2nd ed.
Lady's Mantle Alchemillae herba Alchemilla vulgaris L. s.l. None reported. 2013, Online
Lavender oil/flower Lavandulae aetheroleum/flos Lavandula angustifolia Mill. (syn. Lavandula officinalis Chaix) None reported. 2009, Suppl. 2nd ed.
Lime flower Tiliae flos Tilia cordata Miller, Tilia platyphyllos Scop., Tilia × vulgaris Hayne (syn. Tilia x europaea L.) None reported. 2022, Online
Linseed Lini semen Linum usitatissimum L. The absorption of other medications taken at the same time may be delayed. For this reason, other medications should be taken at least 30-60 minutes before linseed.
Diabetics should be aware of a potential delay in glucose absorption.
2017, Online
Liquorice root Liquiritiae radix Glycyrrhiza glabra L., Glycyrrhiza inflata Batalin, Glycyrrhiza uralensis Fisch. Hypokalaemia (resulting from excessive use of liquorice root) may potentiate the action of cardiac glycosides and interact with antiarrhythmic drugs or drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adrenocorticosteroids and stimulant laxatives) may aggravate electrolyte imbalance. 2003, 2nd ed.
Mallow flower Malvae flos Malva sylvestris L. None reported. 2016, Online
Marshmallow root Althaeae radix Althaea officinalis L. The absorption of other medications taken at the same time may be delayed. For this reason, other medications should be taken at least 30-60 minutes before marshmallow root. 2019, Online
Matricaria flower Matricariae flos Matricaria recutita L. (syn. Chamomilla recutita (L.) Rauschert) None reported. 2020, Online
Meadowsweet Filipendulae ulmariae herba Filipendula ulmaria (L.) Maxim. (syn. Spiraea ulmaria L.) None reported. 2015, Online
Melilot Meliloti herba Melilotus officinalis (L.) Lam. None reported. 2003, 2nd ed.
Melissa leaf Melissae folium Melissa officinalis L. None reported. 2013, Online
Milk Thistle fruit Silybi mariani fructus Silybum marianum (L.) Gaertn. None reported. 2009, Suppl. 2nd ed.
Motherwort Leonuri cardiacae herba Leonurus cardiaca L. None reported. 2019, Online
Mullein flower Verbasci flos Verbascum thapsus L., Verbascum densiflorum Bertol. (syn. Verbascum thapsiforme Schrad), Verbascum phlomoides L. None reported. 2014, Online
Myrrh Myrrha Commiphora myrrha (Nees) Engl. (syn. Commiphora molmol (Engl.) Engl. ex Tschirch) None reported. 2014, Online
Narrow-leafed Coneflower root Echinaceae angustifoliae radix Echinacea angustifolia DC. None reported. 2019, Online
Nettle leaf/herb Urticae folium/herba Urtica dioica L., Urtica urens L. None reported. 2018, Online
Nettle root Urticae radix Urtica dioica L., Urtica urens L. None reported. 2015, Online
Pale Coneflower root Echinaceae pallidae radix Echinacea pallida Nutt. None reported. 2018, Online
Passion flower Passiflorae herba Passiflora incarnata L. None reported. 2003, 2nd ed.
Pelargonium root Pelargonii radix Pelargonium sidoides DC., Pelargonium reniforme Curt. None reported. 2015, Online
Peppermint leaf Menthae piperitae folium Mentha x piperita L. None reported. 2019, Online
Peppermint oil Menthae piperitae aetheroleum Mentha x piperita L. Patients with achlorhydria (caused e.g. by medication with H2 receptor blockers) should use peppermint oil only in enteric coated capsules. 2003, 2nd ed.
Primula root Primulae radix Primula veris L., Primula elatior Hil. None reported. 2021, Online
Psyllium seed Psylli semen Plantago afra L. (syn. Plantago psyllium L.), Plantago indica L. (syn. Plantago arenaria Waldst. et Kit.) Enteral absorption of concomitantly administered minerals (e.g. calcium, iron, lithium, zinc), vitamins (B12), cardiac glycosides and coumarin derivatives may be delayed. For this reason, other medications should be taken at least 30-60 minutes before psyllium seed.
In the case of insulin-dependent diabetics it may be necessary to reduce the insulin dose.
2017, Online
Pumpkin seed Cucurbitae semen Cucurbita pepo L. None reported. 2009, Suppl. 2nd ed.
Purple Coneflower herb Echinaceae purpureae herba Echinacea purpurea (L.) Moench None reported. 2021, Online
Purple Coneflower root Echinaceae purpureae radix Echinacea purpurea (L.) Moench None reported. 2021, Online
Pygeum bark Pruni africanae cortex Prunus africana (Hook.f.) Kalkman (syn. Pygeum africanum Hook.f.) None reported. 2020, Online
Red Vine leaf Vitis viniferae folium Vitis vinifera L. None reported. 2020, Online
Restharrow root Ononidis radix Ononis spinosa L. None reported. 2015, Online
Rhatany root Ratanhiae radix Krameria triandra Ruiz et Pav. None reported. 2017, Online
Rhubarb Rhei radix Rheum palmatum L., Rheum officinale Baill. Hypokalaemia (resulting from long term laxative abuse) potentiates the action of cardiac glycosides and interacts with anti-arrhythmic drugs or with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adreno-corticosteroids and liquorice root) may aggravate electrolyte imbalance. 2018, Online
Ribwort Plantain leaf/herb Plantaginis lanceolatae folium/herba Plantago lanceolata L. s.l. None reported. 2013, Online
Roman Chamomile flower Chamomillae romanae flos Chamaemelum nobile (L.) All. (syn. Anthemis nobilis L.) None reported. 2019, Online
Rosemary leaf Rosmarini folium Rosmarinus officinalis L. None reported. 2003, 2nd ed.
Sage leaf Salviae officinalis folium Salvia officinalis L. None reported. 2021, Online
Sage leaf, Three-lobed Salviae trilobae folium Salvia fruticosa Mill. (syn. Salvia triloba L.f.) None reported. 2014, Online
Saw Palmetto fruit Serenoae repentis fructus Serenoa repens (W. Bartram) Small (syn. Sabal serrulata (Michx.) Schult. f) Few case reports of suspected interactions with warfarin. Increased International Normalized Ratio (INR) values have been described. 2003, 2nd ed.
Senega root Polygalae radix Polygala senega L. None reported. 2003, 2nd ed.
Senna leaf Sennae folium Cassia senna L. (syn. Cassia acutifolia Delile), Cassia angustifolia Vahl Hypokalaemia (resulting from long term laxative abuse) potentiates the action of cardiac glycosides and interacts with anti-arrhythmic drugs or with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adreno-corticosteroids and liquorice root) may aggravate electrolyte imbalance. 2003, 2nd ed.
Senna pods Sennae fructus Cassia senna L. (syn. Cassia acutifolia Delile) Hypokalaemia (resulting from long term laxative abuse) potentiates the action of cardiac glycosides and interacts with anti-arrhythmic drugs or with drugs which induce reversion to sinus rhythm (e.g. quinidine). Concomitant use with other drugs inducing hypokalaemia (e.g. thiazide diuretics, adreno-corticosteroids and liquorice root) may aggravate electrolyte imbalance. 2003, 2nd ed.
St. John's Wort Hyperici herba Hypericum perforatum L. Oral administration of preparations with a daily dose of more than 1000 mg drug equivalent or more than 1 mg hyperforin can lead to induction of enzymes of the cytochrome P450 family and the P-glycoprotein drug efflux transporter. Interactions can occur with drugs including amitryptiline, fexofenadine, benzodiazepines, methadone, simvastatin, finasteride, digoxin.
Concomitant use of cyclosporine, tacrolimus for systemic use, amprenavir, indinavir and other protease inhibitors, irinotecan and anticoagulants (e.g. warfarin or phenprocoumon) is contraindicated.
The reduction of plasma concentrations of oral contraceptives could cause mid-cycle bleeding. The use of additional contraceptive measures due to a possible reduction in contraceptive efficacy is recommended.
Several cases of serotonergic effects after concomitant use of St. John's wort preparations with certain antidepressants have been reported. The attribution of these cases to St. John's wort remains unclear.
Patients taking other medicines on prescription should consult a physician or pharmacist before taking St. John's wort.
2018, Online
Tea Tree oil Melaleucae aetheroleum Melaleuca alternifolia (Maiden et Betche) Cheel, Melaleuca linariifolia Sm., Melaleuca dissitiflora F. Muell. None reported. 2003, 2nd ed.
Thyme Thymi herba Thymus vulgaris L., Thymus zygis L. None reported. 2003, 2nd ed.
Tormentil Tormentillae rhizoma Potentilla erecta (L.) Raeusch. (syn. Potentilla tormentilla Stokes) None reported. 2013, Online
Turmeric Curcumae longae rhizoma Curcuma longa L. (syn. Curcuma domestica Valeton) None reported. 2003, 2nd ed.
Valerian root Valerianae radix Valeriana officinalis L. s.l. None reported. 2003, 2nd ed.
White Horehound Marrubii herba Marrubium vulgare L. There are reports from a clinical trial with diabetic patients taking glibenclamide that consumption of an aqueous extract was linked with minor symptoms of nausea, oral dryness or salivation, and dizziness. 2013, Online
Wild Pansy Violae herba cum florae Viola arvensis Murray, Viola tricolor L. None reported. 2015, Online
Wild Thyme Serpylli herba Thymus serpyllum L. s.l. None reported. 2014, Online
Willow bark Salicis cortex Salix purpurea L., Salix daphnoides Vill., Salix fragilis L. Willow bark may slightly increase the effects of oral anticoagulants. 2017, Online
Wormwood Absinthii herba Artemisia absinthium L. None reported. 2003, 2nd ed.
Yarrow Millefolii herba Achillea millefolium L. None reported. 2021, Online

 

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