G6PD 억제제-?Ketotifen?

2009

https://www.tandfonline.com/doi/full/10.3109/14756360903489581

Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study

Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study

 

Table II.  IC50 values and Ki constants obtained from inhibition percent values vs five different inhibitors

 

Drugs                                                IC50 (mM)                 Ki (mM)                Inhibition type

Ketotifen	0.008	0.0052 ± 0.0012	Non-competitive
Dacarbazine	0.021	0.0154 ± 0.0011	Non-competitive
Thiocolchicoside	0.056	0.0397 ± 0.0063	Non-competitive
Meloxicam	0.067	0.0579 ± 0.0061	Non-competitive
Methotrexat	0.114	0.0910 ± 0.0166	Non-competitive
Furosemide	0.315	0.1874 ± 0.0136	Non-competitive
Olanzapine	0.53	0.4972 ± 0.0710	Non-competitive
Methylprednizolone acetate	2.23	0.5405 ± 0.1528	Competitive
Paricalcitol	2.28	4.2867 ± 1.0670	Non-competitive
Ritodrine hydrochloride	8.11	8.2081 ± 1.3522	Non-competitive
Gadobenate-dimeglumine	115	48.4380 ± 2.176	Non-competitive

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