https://onlinelibrary.wiley.com/doi/full/10.1111/cas.12085
Cancer metabolism: Key players in metabolic reprogramming
Over 80 years ago, Warburg discovered that cancer cells generate ATP through the glycolytic pathway, even in the presence of oxygen. The finding of this phenomenon, termed the “Warburg effect,” stimu...
onlinelibrary.wiley.com
Target genes of HIF, c-Myc and p53 associated with energy metabolism
PathwaysTarget genesTranscription factors
| Transporter | Glucose transporter 1 | HIF, c-Myc and p53 |
| Glucose transporter 2 | c-Myc | |
| Glucose transporter 3 | HIF and p53 | |
| Glucose transporter 4 | c-Myc and p53 | |
| Glycolysis | Hexokinase 2 | HIF, c-Myc and p53 |
| Phosphofructokinase 1 | HIF and c-Myc | |
| Aldolase A | HIF and c-Myc | |
| GAPDH | HIF and c-Myc | |
| Phosphoglycerate kinase 1 | HIF and c-Myc | |
| Phosphoglycerate mutase | p53 | |
| Enolase 1 | HIF and c-Myc | |
| Pyruvate kinase M2 | HIF and c-Myc | |
| Lactate dehydrogenase A | HIF and c-Myc | |
| Pentose phosphate | Transketolase | HIF |
| Transketolase-like protein 2 | HIF | |
| TCA cycle | Pyruvate dehydrogenase kinase 1 | HIF and c-Myc |
| Glutaminase 2 | p53 | |
| Anabolic | CAD | c-Myc |
| Serine hydroxymethyltransferase | c-Myc | |
| Fatty acid synthase | c-Myc | |
| Ornithine decarboxylase | c-Myc |
- CAD, carbomyl phosphate synthetase aspartate transcarbomylase and dihydroorotase; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; HIF, hypoxia-inducible factor; TCA, tricarboxylic acid.
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