? Orlistat-associated adverse effects and drug interactions

https://d1wqtxts1xzle7.cloudfront.net/41886071/Orlistat-Associated_Adverse_Effects_and_20160202-27164-9jy19t-with-cover-page-v2.pdf?Expires=1628759391&Signature=CkjMfdh2mIsJhddLKUuFRkiVjUk2TKFj7BA3bYjaQb8M3xgFXFGV5~bg8tVllfl6qx3drhnovsTsdH1BbR7ufL0JjjBEl~Rcmujjbzte3gwMzuOMO7BoXX6gnAs4NuP~5wZqnvJpKwtHcfgS3gGsi~1CXtZJAJSnjWfk1W-YxuU4QsnfXC8OuJvlQcx5oyzKbZIsmn17wPlluXL3C10mRO0picQoMhAgHFG~1PNWluKJver70AokwcykYY3R9q2gkPi2hI2dv4ydWdA-8rbobDyrpFgg2Q1043Qk5rSKYpatO3c7jGdhOL-RALB5vQ55KHmQt5Z1VqM6k0WDG6drIQ__&Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA 

 

 

orlistat may be listat does not significantly alter the pharmaco- used during long-term pharmacotherapy in over- kinetics of glibenclamide (glyburide),[133] or metfor- weight and obese psychiatric patients. In addition, min.[119] However, there is evidence that the combi- orlistat was beneficial in the treatment of clozapine- nation of orlistat with sulfonylureas or metformin induced hyperglycaemia and weight gain in a causes increased episodes of mild to moderate hypo- 35-year-old man with chronic schizophrenia.[124] glycaemia compared with placebo in diabetic patients.

 

Orlistat had no significant effect on the Acknowledgements pharmacokinetics of phenytoin,[134] fluoxetine,[112]amitriptyline,[119] phentermine,[119] sibutramine,

No sources of funding were used to assist in the preparadigoxin,[3] losartan,[119] atenolol,[135] furosemide,[135] tion of this review. 

Some of the authors have given talks,attended conferences and participated in trials and advisory
captopril,[135] nifedipine,[135,136] pravastatin,boards sponsored by various pharmaceutical companies insimvastatin[112] or atorvastatin.[119]

orlistat has added beneficial effects on metabolic parameters when co-administered with References
statins[137] or fibrates[49,50] in overweight and obese 1.

Dahlin A, Beermann B. Incorrect use of orlistat and sibutramine patients with hypercholesterolaemia or metabolic in clinical practice.