Synergies (암 치료에 시너지효과를 일으키는 보충제들)

 

 

https://synergiesforcancertreatments.blogspot.com/p/synergies.html

Synergies ⚡

 

 

Synergy: two or more substances can be greater than the sum of their parts. (tip: Ctrl+F ⌨ to search this page)

1. Garlic + Turmeric anticholesterol effect {study┃The role of cholesterol metabolism in cancer}
2. Tomato (lycopene) + broccoli (sulforaphane): daily 1.4 cups of raw broccoli and 2.5 cups of fresh tomato, or 1 cup of tomato sauce, or 1/2 cup of tomato paste.  {article} prostate health/prevention
3. Turmeric + garlic + ginger {study}
4. Honokiol + Magnolol
5. Honokiol + Modified Citrus Pectin {link}
6. Selenium + sulforaphane: up to 13 times more effective than either nutrient alone. {article}
7. Vit C(ascorbic acid) + Vitamin K3 100:1 {study}
8. Lysine + Ascorbic acid + Green Tea Extract 
9. EGCG + Quercetin {study|study|study}
10. Luteolin + EGCG {study| study}
11. IP6 + Inositol
12. IP6 + catechins catechin and IP6 amplified VEGF reduction {study}
13. Garcinol + Curcumin: 2 to 10 fold that of the individual agents on pancreatic cancer cells.
14. Grape Seed Extract + Green Tea
15. Green tea + Curcumin {study|study ↑p21|study|study}
16. Curcumin + Boswellia {video}
17. Curcumin + Berberine
18. Curcumin + Ursolic Acid
19. Curcumin + Ascorbic acid {Curcumin antifungal and antioxidant activities are increased 5-10 fold in the presence of ascorbic acid study}
20. Ascorbic acid, Zinc, Selenium, and Quercetin
21. Pomegranate, Broccoli, Turmeric and Green tea.
22. Laetrile, Ascorbic acid and pancreatic enzymes.
23. Vitamin D + Lycopene {study inhibition of prostate and mammary cancer cells | study leukemic cells} 
24. Garlic + Artesunate {study}
25. D-limonene + Berberine {study┋stomach cancer}
26. Maitake + Ascorbic acid {study┋hepatocellular carcinoma}
27. Carnosic acid + Curcumin {study}
28. Curcumin + black seed oil antiviral {study}
29. Curcumin + DHA docosahexaenoic acid {study}
30. Curcumin + Ascorbic acid {study} "both natural products may work together by different molecular pathways to achieve their overall cytotoxicity. Unlike chemically synthesized drugs, natural products might be active at lower doses and over longer periods of incubation, which could further support the appearance of additive effects."
31. Vitamin D3 + Sulforophane {study|study|study|study|article}
32. Melatonin + Vitamin D3 {study|study}
33. Curcumin + Sulforaphane {study|study|study "Data from this study demonstrate that a low-dose ACS combination inhibits cell growth by inducing cell apoptosis, and proposes sustained activation of the ERK1/2signaling pathway as one of the possible mechanisms"}
34. Curcumin + Silymarin {study}
35. Aspirin + Curcumin + Sulforaphane " From our studies, we report a 2–5-fold reduction in doses with ASP (1 mM) and CUR (10 μM). Similarly, 20–40 μM of SFN is reported to be active against various cancers, whereas our dose of 5 μM concentration in combination with ASP and CUR reduced the concentration by 4–8 times (18,21,22). Subsequent studies using apoptosis and colony formation assays confirmed these observations and further strengthen the hypothesis of synergistic effect using combinatorial regimens" {study}
36. EGCg + Capsaicin: Catechin-vanilloid synergies with potential clinical applications in cancer.
37. Curcumin + Honokiol + Apigenin: {study}
38. Sulforaphane + EGCg: {study}
39. Galangin + Berberine: {study}
40. Fucoidan + Rutin: {study}
41. Maitake + Sulforaphane: "synergistic effect of the combination of sulforaphane and a maitake extract on the gene expression of Phase 2 detoxifying enzymes NQO1 and UGT1A1 suggesting the agents together may be effective at detoxifying the body of excess estrogens"{article}
42. EGCg (green tea) + lemon: "Citrus juices, including fromlimes, grapefruits, lemons and oranges,increased the levels of catechins by more than five times, with an 81 to 98 per cent recovery for EGC, 56 to 75 per cent for EGCG, 86 to 95 per cent for EC and 30 to 55 per cent for ECG. Lemon juice was the most effective at preserving catechins in green tea, the study found."{article}
43. Vitamin C (ascorbic acid) + Vitamin B2: {study}
44. Curcumin + Triptolide:{study}
45. Emodin + Curcumin: {study|study}
46. Resveratrol + Artemisinin: {study}
47. Curcumin + Resveratrol: {study}
48. EGCG + Silibinin: {study}
49. Thymoquinone + Melatonin: {study}
50. Cucurbitacin B + Curcumin: {study}
51. Lipoic acid + hydroxycitrate: "The combination was used to treat mouse syngeneic cancer models: MBT-2 bladder transitional cell carcinoma, B16-F10 melanoma and LL/2 Lewis lung carcinoma. The efficacy of this combination appears similar to conventional chemotherapy (cisplatin or 5-fluorouracil) as it resulted in significant tumor growth retardation and enhanced survival." {study| + capsaicin study} 
52. Shark liver oil + theobromine {book} anti-angiogenisis, tumor suppression
53. Citrus limonoids + Curcumin: {study} 
54. Curcumin + Ginger + Rutin: {study}
55. Rutin + Silibinin: {study}
56. Oligomeric proanthocyanidins (OPCs) + Curcumin: {study}
57. Sodium butyrate + artemisinin: {study}
58. Berberine + Curcumin + Dihydroartemisinin: HDAC inhibition {article}
59. Astragalus + Salvia Miltiorrhiza: {study}
60. Baicalin + Salvia Miltiorrhiza: {study}
61. Mesoinositol + ascorbic acid: {study}
62. Ferulic acid + Curcumin: {study}
63. Curcumin + Sulforaphane + Dihydrocaffeic Acid:{study┋colon cancer}
64. Piperlongumine + Sanguinarine: {study}
65. Luteolin + Palmitoylethanolamide: {study} Autophagy inhibition
66. DHA + Butyrate: {study}
67. β-cryptoxanthin + Lycopene {study|article}
68. Butyrate + Acetylcarnitine:{study┋colon cancer}
69. Luteolin + Myo-inositol: {study┋lung cancer}
70. Melatonin + aloe vera: {study}
71. Ellagic acid + Quercetin: {study}
72. Ginger + Licorice Extract: {study}
73. Glycyrrhetinic acid + Curcumin {study ┋HCC}
74. Butyrate + Vitamin A: {study}
75. Calcitriol + Curcumin: {study}
76. Calcitriol + Resveratrol: {study}
77. DHA Dihydroartemisinin + Curcumin: {study}
78. Aloe vera + butyrate {study}
79. Vitamin D + Sodium butyrate {study}

Synergetic combinations of Supplements/herbs and prescription/OTC drugs

 

• Melatonin + Tamoxifen {study}
• Aspirin + Curcumin/Turmeric {article}
• Metformin + Vitamin D3 {article}
• Hydroxycitric acid + Tamoxifen {study}
• Curcumin + docetaxel: Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin {study| study}
• Berberine + sorafenib: {study}
• White & green tea + Sulindac: {study}
• EGCg + Sulindac/Tamoxifen:{study}
• Guaraná + oxaliplatin: {study}
• Caffeine + immune checkpoint inhibitors: {study}
• Honokiol + Adriamycin: {study}
• Caffeine citrate + cisplatin: {study}
• Ibuprofen + EGCg: {study}
• Curcumin + antibiotics: "Antibiotics classes that have shown synergism with curcumin include β-lactams, Cephalosporins, Aminoglycosides, Glycopeptides, Tetracyclines, and Fluoroquinolones."{review}
• Iodine + Zoledronate: {study┋TNBC} 
• Hesperidin + apigenin + doxorubicin: {study}
• Berberine + Tamoxifen: {study}
• Artesunate + HDACi: {article}
• Sodium Butyrate + Metformin: {study}
• Mebendazole + Chloroquine: {ref}
• Mebendazole + trametinib: {study}
• Metformin + Quercetin: {study}
• Low dose naltrexone + Vitamin D: {case report┋adenoid cystic tongue carcinoma}
• Aminolevulinic acid + artemisinin: {study}
• Aloe vera + Metformin {study}
• HDACi + DNA-damaging agents: {study}
• Vorinostat + EGCG {study}
• scriptaid + bortezomib: {study┋ovarian cancer}
• Curcumin + Celecoxib: {study⏐study}
• IP6 + Tamoxifen:{study}
• Tamoxifen + EGCG: {study}
• Luteolin + celecoxib:{study}
• Luteolin + Tamoxifen:{study}
• Garlic + antibiotics: {study}
• Hydroxycitric acid (HCA) + Tamoxifen:{study}
• Black cohosh + Tamoxifen: {ref}
• Tamoxifen + Calcitriol: {study}
• Ellagic Acid + Sorafenib: {study}
• Stinging nettle + cisplatin {study}
• Allicin + 5-Fluorouracil {study}
• 5-fluorouracil + fish oil {study}
• Butyrate + 5-FU {study}
• Quercetin + Phenmorfin {study}

⚠ Cautions regarding combining supplements and medication. Stop taking supplements 2 weeks prior to surgery, or consult with your surgeon. If you take medications check if the supplement(s) can be combined with those drugs, especially with chemotherapy, diabetes medications, anticoagulant and antiplatelet medications (including aspirin), benzodiazepines, etc. To combine various supplements add one at a time, start with the lowest possible dose, and gradually increase if no side effect is observed. And of course, consult your doctor.

 

 

 

References & Sources

• Anti-cancer potential of a mix of natural extracts of turmeric, ginger, and garlic: A cell-based study
• Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment
• Food Synergy by Elaine Magee
• https://www.ncbi.nlm.nih.gov/pubmed/23902242
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036554/
• https://www.ncbi.nlm.nih.gov/pubmed/15879623
• http://lifeovercancerblog.typepad.com/life-over-cancer-blog/2011/05/supplements-and-conventional-cancer-treatment-an-exploration-of-potential-synergies.html
• https://www.ncbi.nlm.nih.gov/pubmed/17018899
• http://www4.dr-rath-foundation.org/NHC/cancer/cellular_solutions.htm
• Dr. Rath Cellular Solution
• https://www.ncbi.nlm.nih.gov/pubmed/20717705
• https://www.ncbi.nlm.nih.gov/pubmed/27618095
• https://www.ncbi.nlm.nih.gov/pubmed/22685460
• https://www.researchgate.net/publication/304339081_Synergistic_Anticancer_Potential_of_Water_Garlic_Extract_and_Copper_in_a_Human_Hepatocarcinoma_Cell_Line
• https://www.researchgate.net/publication/332471611_Synergistic_Effects_of_Plant_Derivatives_and_Conventional_Chemotherapeutic_Agents_An_Update_on_the_Cancer_Perspective
• https://www.frontiersin.org/articles/10.3389/fphar.2018.01534/full
• What Does It Take to Synergistically Combine Sub-Potent Natural Products into Drug-Level Potent Combinations?
• Synergistic Anticancer Activity of Combined Use of Caffeic Acid with Paclitaxel Enhances Apoptosis of Non-Small-Cell Lung Cancer H1299 Cells in Vivo and in Vitro
• http://www.ijddr.in/drug-development/combination-of-natural-agent-with-synthetic-drug-for-the-breast-cancertherapy.php?aid=22326
• Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1.
• Naturally occurring compounds as pancreatic cancer therapeutics
• Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate
• Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
• EGCG/CU-loaded nanoparticles
• Ellagic acid, sulforaphane, and ursolic acid in the prevention and therapy of breast cancer: current evidence and future perspectives.
• In vitro-in vivo dose response of ursolic acid, sulforaphane, PEITC, and curcumin in cancer prevention
• Role of dietary phytochemicals in the modulation of miRNA expression: Natural swords combating breast cancer
• https://www.newsmax.com/Health/Headline/turmeric-frankincense-colon-cancer/2015/05/20/id/645858/
• https://www.cancernetwork.com/oncology-journal/herb-drug-interactions-cancer-care/page/0/1
• https://return2health.com.au/articles/vitamin-mineral-antagonists
• https://www.researchgate.net/publication/338303948_A_cocktail_of_betulinic_acid_parthenolide_honokiol_and_ginsenoside_Rh2_in_liposome_systems_for_lung_cancer_treatment
• https://www.researchgate.net/publication/312601602_Out_of_Warburg_Effect_an_effective_cancer_treatment_targeting_the_tumor_specific_metabolism_and_dysregulated_pH
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods
• https://www.researchgate.net/publication/292947920_Synergy_in_Herbal_Medicines_Part_1
• https://pubmed.ncbi.nlm.nih.gov/24874360/
• https://www.parentingscience.com/iron-absorption.html
• Antimalarial drug synergism and antagonism: Mechanistic and clinical significance
• Natural product-derived therapy for gynecologic cancers: A therapeutic mix encompassing Berberine (BER), Dihydroartemisinin (DHA), and Curcumin (CUR)inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene
• Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials
• Vitamin and Mineral Interactions: The Complex Relationship of Essential Nutrients