Repurposing drugs in oncology: From candidate selection to clinical adoption
https://www.sciencedirect.com/science/article/pii/S1044579X20300110
Repurposing drugs in oncology: From candidate selection to clinical adoption
Drug repurposing is a strategy that aims to develop novel cancer treatments through the reuse of existing medicines developed in other disease areas. …
www.sciencedirect.com
Table 1. Osteosarcoma repurposing candidates and mechanisms of action.
Mechanism of ActionDrug (main indication)Type of evidenceCell differentiationCytotoxicity & potentiation of chemotherapyStem cells cytotoxictyImmunomodulationEpigenetic modificationsCell-cell interaction
| Calcitriol (vitamin D deficiency) | Animal model |
| Simvastatin (hypercholesterolemia) | Animal model |
| Glucocorticoids (inflammation) | Animal model |
| Caffeine (infant apnea) | Human trial / Animal model |
| Esomeprazole (peptic ulcer) | Human trial / Animal model |
| Verapamil (hypertension) | Case reports / In vitro |
| Piroxicam (osteoarthritis) | Canine trials / Animal model |
| Metformin (type 2 diabetes) | Animal model |
| Disulfiram (alcohol dependency) | In vitro |
| Sirolimus (prevention organ rejection) | Human trial / Animal model |
| Valproic acid (epilepsy) | Animal model |
| Aspirin (CVD prevention) | Animal model |
| Heparin (VTE) | Animal model |
| Warfarin (embolisation) | Human trial / Animal model |
| Plerixafor (stem cell mobilization) | Animal model |
CVD – cardiovascular diseases; VTE – venous thromboembolism.
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