암 줄기 세포에 대한 치료 도구로서의 파이토케미칼

 

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519921/

<Phytochemicals as Innovative Therapeutic Tools against Cancer Stem Cells>

 

자가 재생의 분자 메커니즘

암 줄기 세포에서 자가 재생 유전자의 발현을 조절하는 Wnt/β-카테닌의 신호 전달 네트워크. 

 

Wnt가 있으면 GSK-3β가 억제되고 β-카테닌이 세포질에서 핵으로 전위되어 결과적으로 자가 재생 표적 유전자 전사가 활성화됩니다. 

 

약어: GSK-3β, 글리코겐신타제키나제-3β; TCF, T 세포 인자; LEF, 림프구 증강 인자; Wnt, 윙리스 관련 통합 사이트.

 

Table 2

Phytochemicals that are able to kill the cancer stem cells of tumors through specific molecular mechanisms.

Phytochemicals or Extracts      CSCs Type                   Molecular Mechanism                                 Reference

EGCG	Breast cancer	Inhibits Wnt signaling	[88]
Piperine	Breast cancer	Inhibits Wnt signaling	[79]
Sulforaphane	Breast cancer	Decreases ALDH1 activity	[77]
		Inhibits Wnt signaling
	Pancreatic cancer	Induces apoptosis, activating caspase 3	[89]
		Downregulates β-catenin
β-Carotene	Neuroblastoma	Inhibits Wnt signaling	[86]
		Induces CSC differentiation
Quercetin	Pancreatic cancer	Inhibits Wnt signaling	[90]
Resveratrol	Pancreatic cancer	Induces apoptosis, activating caspase 3	[91]
	Colorectal cancer	Inhibits Wnt signaling	[92]
Genistein	Pancreatic cancer	Decreases number of mammospheres	[92]
		Decrease number of CD44+ cells
Curcumin	Breast cancer	Decreases number of mammospheres	[79]
		Decreases ALDH1 activity
	Colon cancer	Decreases ALDH1 activity	[93]
		Decreases number of CD44+, CD133+, CD166+ cells
		Induces apoptosis
	Colorectal cancer	Induces G2/M phase arrest	[94]
		Downregulates β-catenin
	Prostate cancer	Induces G2/M phase arrest	[95]
		Inhibits Wnt signaling
Sasa quelpaertensis extract	Colon cancer	Induces CSC differentiation	[13]
		Inhibits Wnt signaling