종양 치료제의 약물 용도 변경

2020

Drug Repurposing in Oncotherapeutics

https://www.intechopen.com/chapters/72049

Drug Repurposing in Oncotherapeutics

 

다음 표(표 1)는 약물 용도 변경에 사용할 수 있는 우수한 약물 후보와 이미 승인된 일부 후보에 대한 간략한 검토로 구성됩니다.

Drug First approved target                     Approved in disease         Repurposed in cancer (preclinical/clinical)

   

Thalidomide	Might affect the medullary control centers (the vomiting center and the chemoreceptive trigger zone) or affect the peripheral receptors	Nausea, vomiting of pregnant woman (banned now)	Multiple myeloma by targeting TNF-α
Metformin	Activate the adenosine monophosphate activated protein kinase (AMPK) signaling pathway	Type-II diabetes mellitus	Mitochondrial respiration, reducing insulin and insulin-like growth factor levels, inhibits mTOR and activate p53, AMPK pathway
Everolimus	mTOR	Immunosuppressant	In Pancreatic neuroendocrine by targeting mTOR signaling pathway
Trastuzumab	HER2	HER2-positive breast cancer	For HER2-positive metastatic gastric cancer
Aspirin (low dose; 50–100 mg daily)	COX-1	Prevent Platelets aggregation in cardiovascular disease	Prostaglandin E2 (PGE2) decreased in colon cancer [18], inhibition of platelets to suppress NK cell-mediated lysis of cancer cells [19]
Propranolol	β-receptor blocker	Cardiovascular diseases	Reduced 57% risk of metastasis in Breast cancer by blocking cyclic AMP (cAMP), focal adhesion kinase (FAK)
Digoxin	Na + -K + -ATPase	Heart failure, to reduce heart rate	Rise in intracellular Na + and Ca2+ in human prostate adenocarcinoma cells, lead to activation of calcineurin and transcriptional upregulation of Fas ligand cause apoptosis. Also, suppression nuclear factor-kappa B and inhibition of DNA topoisomerase II are well documented.
Chlorpromazine	Dopamine receptor antagonist	In psychosis, bipolar disorder, schizophrenia	Increase in p21 [23], p51 expression [24]
Artemisinins	Induce formation of reactive oxygen species (ROS) within the infected red blood cells (RBC)	Anti-malarial [25]	Anti-proliferative, pro-apoptotic effects [26]
Doxycycline	Protein synthesis in bacteria	Antibiotics	Down regulation of MMP-2 and MMP-9 expression in leukemia [27] and colorectal cancer cells [28]

Table 1.

암 치료를 위한 용도 변경 약물.

 

암의 홀 마크.

 

약물 및 질병 검색 옵션을 기반으로 한 약물 용도 변경 현황은 repoDB 사이트에서 확인할 수 있습니다. 이 약물 재배치 데이터베이스에는 2051개 질병에 대한 정보가 포함되어 있으며, 모두 쉽게 통합할 수 있도록 UMLS 용어에 매핑됩니다[ 50 ].

• http://apps.chiragjpgroup.org/repoDB/