2013
HERB-DRUG INTERACTION: AN OVERVIEW
http://ijpsr.com/bft-article/herb-drug-interaction-an-overview/?view=fulltext
HERB-DRUG INTERACTION: AN OVERVIEW | INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
Plants have always provided an important source of medicines. They may be used by natives in folk medicine and later adopted by conventional western medicine as their efficacy was confirmed. Any pharmacological modification caused by herbal substances to a
ijpsr.com
SOME SELECTED HERB-DRUG INTERACTION
| S. No. | HERB | COMMON USE | MAY INTERACT WITH | POTENTIAL EFFECT |
| 1 | Aloe vera | Strong cathartic | Cardiac glycosides, Thiazide diuretics 23 |
Can cause electrolyte imbalance and hypokalemia; May potentiate drug toxicity |
| 2 | Bearberry | Urinary tract antibacterial, astringent, diuretic |
Urinary acidifiers, Cranberry juice 22 |
Inactivated by urinary acidifiers; active compound released only in alkaline urine. |
| 3 | Cascara | Stimulant laxative | Cardiac glycosides, Thiazide diuretics 23 | Can cause electrolyte imbalance and hypokalemia; May potentiate drug toxicity |
| 4 | Garlic (Allium sativum) |
Hyperlipidemia | Anticoagulants Antiplatelet agents 22, 24 |
Inhibits platelet aggregation; Additive anticoagulant, antiplatelet effects |
| 5 | Ginger | Motion sickness, nausea, arthritis |
Anticoagulants, Antiplatelet agents 22,24 | Inhibits thromboxane synthetase; may have additive anticoagulant, antiplatelet effects |
| 6 | Karela (Bitter melon) |
Diabetes mellitus | Hypoglycemic drugs24 | Potentiates drug effect |
| 7 | Ma-huang Ephedra, squaw tea, mormon tea, popotillo, sea grape (Ephedra species) |
Asthma, weight loss | Oxytocin, Methyldopa, b-blockers, Caffeine, Monoamine oxidase inhibitors, Theophylline, Sympatho-mimetics, St. John’s wort, Guanethidine, Cardiac glycosides 23, 25 | Increased sympathomimetic action; may induce hypertension, CNS stimulation |
| 8 | Senna Cassia acutifolia, C.augustifolia, Senna alexadrina) |
Constipation | Digitalis, Diuretics 23, 10 | Chronic use may cause hypokalemia and potentiate drug toxicity |
| 9 | St. John’s Wort (Hypericum perforatum) |
Depression | Antidepressants, sympathomimetic amines, Ma Huang, pseudoephedrine, yohimbine 23,24 |
Herb may have monoamine oxidase inhibitor or selective serotonin reuptake inhibitor effects; Possible hypertensive crisis, serotonin syndromes |
| 10 | Turmeric Tumeric, indian saffron (Curcuma longa) |
Dyspepsia | Antiplatelet agents 22 | Herb contains curcumin; may potentiate antiplatelet activity |
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