Nrf2 와 FN3K

https://www.mdpi.com/2072-6694/13/2/281/htm

 

Nrf2의 탈당화는 FN3K에 의해 촉매되며,

FN3K의 활성은 암세포가 악성 및 약물 내성 표현형으로 진행되는 동안 향상됩니다. 

따라서 Nrf2의 탈당화는 부분적으로 암세포의 종양 발생 가능성에 기여할 수 있는 중요한 메커니즘 중 하나입니다.

Table 2. Phytochemicals and drug interventions that modulate AGE-RAGE-mediated glycation to mitigate cancer cell growth.

Phytochemical                      Signaling Pathways                                        Cancers Refs

Papavarine	Downregulation of HMBG1, RAGE, and NF-κB	Fibrosarcoma	[20]
	Downregulation of HMBG1 and RAGE	Glioblastoma	[224]
Cinnamic acid	-	Yet to be examined against AGE-RAGE-mediated cancers (?)	[222]
Ellagic acid	-		[218]
Maple syrup	-		[220]
Thiol-amine	-
Drugs
Ergothioneine	Downregulation of AGEs, RAGE, and NF-κB	Pheochromocytoma	[227]
Hispidin		Pheochromocytoma	[227]
Chondroitin sulfate and heparan sulfate	-	Lung metastasis	[226]
Duloxetine	Downregulation of S100B	Glioma cancer	[230]
Ethyl pyruvate	Downregulation of HMBG1, RAGE, and NF-κB	Malignant mesothelioma	[228]
	Downregulation of the HMBG1, RAGE, NF-κB, and STAT3 Pathways	Non-small cell lung cancer	[229]
Low molecular weight heparin	Downregulation of RAGE-mediated NF-kB	Fibrosarcoma	[225]