https://www.nature.com/articles/cddis2011123 Cancer metabolism: current perspectives and future directions - Cell Death & Disease The p53 protein is coded by the TP53 gene, which is the most frequently mutated gene in human tumours and functions as the ‘guardian of the genome’.35 p53 acts as a tetrameric transcription factor that induces hundreds of target genes involved in regul www.nature.com ..