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https://link.springer.com/article/10.1186/s40364-020-00230-3 2020 Targeting ferroptosis in breast cancer https://link.springer.com/article/10.1186/s40364-020-00230-3/tables/1 Table 1 The main morphological features, regulators, inducers and inhibitors of ferroptosis, apoptosis, necroptosis, autophagy-dependent cell death and pyroptosis From: Targeting ferroptosis in breast cancer Cell DeathDefin..

https://www.sciencedirect.com/science/article/abs/pii/S0006291X16313882 Identification of ACSL4 as a biomarker and contributor of ferroptosis Ferroptosis, a recently identified form of non-apoptotic cell death, is involved in several physiological and pathological processes. Although lipid p… www.sciencedirect.com Identification of ACSL4 as a biomarker and contributor of ferroptosis

2018 Till Death Do Us Part: The Marriage of Autophagy and Apoptosis https://www.hindawi.com/journals/omcl/2018/4701275/ Till Death Do Us Part: The Marriage of Autophagy and Apoptosis Autophagy is a widely conserved catabolic process that is necessary for maintaining cellular homeostasis under normal physiological conditions and driving the cell to switch back to this status quo under times of st..

2019 Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells https://www.mdpi.com/2072-6694/11/7/916/htm Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells The transformation of normal cells to the cancerous stage involves multiple genetic changes or mutations leading to hyperproliferation, resistance to apoptosis, and evas..

2018 VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis https://www.frontiersin.org/articles/10.3389/fchem.2018.00108/full VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis Cancer and neurodegeneration are different classes of diseases that share the involvement of mitochondria in their pathogenesis. Where..

2021 Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway https://www.frontiersin.org/articles/10.3389/fphar.2021.639628/full Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway Bioactive plant derived compounds are important for a wide range of therapeutic application..

2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115829/ Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review Bioactive compounds from natural products that induce ER-stress-mediated apoptosis in lung cancer. Family NameCompound Duration/Dosage MechanismReference Paris polyphylla Polyphyllin D 1.8 µM, 8 h CHOP ↑, GRP78/BiP ↑, PDI ↑ cleavage..

2018 The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways https://www.researchgate.net/publication/325099343_The_Application_of_Natural_Products_in_Cancer_Therapy_by_Targeting_Apoptosis_Pathways/link/5f841a4792851c14bcc149d8/download 2. KEY PROTEINS INVOLVED IN THE REGULATION OF APOPTOSIS (세포 사멸 조절에 관여하는 주요 단백질) 2.1. Cytochrome C 2.2. Bcl-2 Family 2.3. P53 2.4. F..

2021 https://www.mdpi.com/2218-273X/11/4/534/htm The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy Cancer is a challenging problem for the global health community, and its increasing burden necessitates seeking novel and alternative therapies. Most cancers share six basic characteristics known as “cancer hallmarks”, including uncontrolled proliferat www...

2016 https://www.sloankettering.edu/sites/default/files/node/12448/document/prashant_monian-final-thesis.pdf 그림 1.1. 포유류 세포에서 세포 사멸의 내인성 및 외인성 경로. 내인성 경로에서 세포 손상 신호는 BH3 전용 단백질을 통해 작용하여 Bax 및 Bak을 활성화하여 미토콘드리아 외막 투과화mitochondrial outer membrane permeabilization (MOMP)를 유도합니다. 그 결과 시토크롬 C(Cyt. C)가 방출되고 카스파제-9(C9)를 활성화하기 위한 구조인 apoptosome이 형성됩니다. Caspase-9는 이펙터 caspase-3 및 -7(C3/7)을 활성화합니다. MOMP는 ..