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2021 https://www.mdpi.com/2072-6694/13/11/2813/htm An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor Hypoxia, a characteristic feature of solid tumors, is associated with the malignant phenotype and therapy resistance of cancers. Hypoxia-inducible factor 1 (HIF-1), which is responsible for the metazoan adaptive response to hypoxia, has been recog..

2016 https://www.sciencedirect.com/science/article/pii/S0163725816300559 Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. At… www.sciencedirect.com Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer 그림 2...

2022 https://www.frontiersin.org/articles/10.3389/fgene.2022.849040/full Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism Metabolic alterations are one of the hallmarks of cancer, which has recently gained great attention. Increased glucose absorption and lactate secretion in cancer cells are characterized by the Warburg effect, whi..

2005 PDF Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1A and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells 레스베라트롤 사용의 주요 관심사 중 하나는 고용량에서 잠재적인 독성입니다. 대부분의 시험관 내 연구에서 레스베라트롤은 5~100umol/L 범위의 농도로 사용되었습니다. 일반적으로 테스트된 대부분의 시스템에서 세포사멸 효과가 나타난 용량은 세포 주기 정지 또는 세포 증식 억제를 유도하는 데 사용된 용량(10 – 30 umol/L)보다 상대적으로 더 높습니다(100 – 300 umol/L). 최근 Tseng ..

2010 https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-143 Potent inhibition of tumoral hypoxia-inducible factor 1α by albendazole - BMC Cancer Background Emerging reports suggest resistance, increased tumor invasiveness and metastasis arising from treatment with drugs targeting vascular endothelial growth factor (VEGF). It is believed that increased tumoral hypoxia plays a promi..

2022 https://www.sciencedirect.com/science/article/abs/pii/S1044579X20302029 Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural Rapid progress in molecular cancer biology coupled with the discovery of novel oncology drugs has opened new horizons for cancer target discovery. As … www.sciencedirect.com Targeting hypoxia-..

2017 https://cdn.mdedge.com/files/s3fs-public/cp01606038.pdf Herb–drug interactions: Caution patients when changing supplements ****************************************************************************************** 2000 Herb-drug interactions https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.319.872&rep=rep1&type=pdf *******************************************************************..

2021 https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-021-01593-8.pdf How cancer cells remodel lipid metabolism: strategies targeting transcription factors 지질 대사의 재프로그래밍은 지질 조절 장애 및 관련 효소 프로필의 변경이 전이 및 치료 내성과 같은 악성 표현형 및 발암 신호와 밀접하게 관련되어 있기 때문에 암세포의 특징으로 점점 더 인정을 받고 있습니다. 이 리뷰에서 우리는 지질의 중요성과 암 지질 대사에 관련된 전사 인자를 뒷받침하는 최근 발견을 설명합니다. 암은 단백질, 핵산, 지질과 같은 많은 세포 구성 요소를 필요로 하는 세포 증식의 근본적인 장..

2019 Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643217/ Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer Metabolic disorders can lead to a scarcity or excess of certain metabolites such as g..

2014 https://www.researchgate.net/profile/Kenneth-Omabe/publication/266749710_Lipid_metabolism_and_cancer_progression_The_missing_target_in_metastatic_cancer_treatment/links/5ac26116a6fdcccda65f798f/Lipid-metabolism-and-cancer-progression-The-missing-target-in-metastatic-cancer-treatment.pdf Lipid metabolism and cancer progression: The missing target in metastatic cancer treatment 악성 세포는 동화 대사에 ..