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2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514969/ Combination therapy in combating cancer 용도가 변경된 아세타졸아미드(AZ)가 인간 신장 암종 세포에서 5-HT 분비 및 증식을 감소시키는 것으로 이전에 보고된 바 있습니다 (5-HT autocrine growth factor) Hypoxia and the carbonic anhydrase pathway 암세포는 정상 세포와 다른 특성을 가지고 있으며 이러한 중요한 특성 중 하나는 부분적으로 불규칙한 혈관 구조로 인한 비정상적인 성장 패턴입니다. 이 비정상적인 성장 패턴은 결과적으로 영양 혈관 사이의 큰 확산 거리를 초래합니다.. 종양에 산소를 공급하는 혈액의 부족은 종..

2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115829/ Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review Bioactive compounds from natural products that induce ER-stress-mediated apoptosis in lung cancer. Family NameCompound Duration/Dosage MechanismReference Paris polyphylla Polyphyllin D 1.8 µM, 8 h CHOP ↑, GRP78/BiP ↑, PDI ↑ cleavage..

2018 The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways https://www.researchgate.net/publication/325099343_The_Application_of_Natural_Products_in_Cancer_Therapy_by_Targeting_Apoptosis_Pathways/link/5f841a4792851c14bcc149d8/download 2. KEY PROTEINS INVOLVED IN THE REGULATION OF APOPTOSIS (세포 사멸 조절에 관여하는 주요 단백질) 2.1. Cytochrome C 2.2. Bcl-2 Family 2.3. P53 2.4. F..

2021 https://www.mdpi.com/2218-273X/11/4/534/htm The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy Cancer is a challenging problem for the global health community, and its increasing burden necessitates seeking novel and alternative therapies. Most cancers share six basic characteristics known as “cancer hallmarks”, including uncontrolled proliferat www...

Emerging agents that target signaling pathways in cancer stem cells 2020 https://link.springer.com/content/pdf/10.1186/s13045-020-00901-6.pdf *******************************************************************

Natural Products Targeting the Mitochondria in Cancers 2020 https://www.mdpi.com/1420-3049/26/1/92/htm Natural Products Targeting the Mitochondria in Cancers There are abundant sources of anticancer drugs in nature that have a broad prospect in anticancer drug discovery. Natural compounds, with biological activities extracted from plants and marine and microbial metabolites, have significant ant..

2021 Mitochondrial metabolism as a target for acute myeloid leukemia treatment https://link.springer.com/article/10.1186/s40170-021-00253-w α-TOS: (+)alpha-tocopheryl succinate; ANT: adenine nucleotide translocator; ATO: arsenic trioxide; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; CPT1: carnitine O-palmitoyltransferase 1; DAP: 2,2-dichloroacetophenone; DCA: dichloroacetate; ddC: 2′3′-dideo..

New Insights into the Epigenetic Activities of Natural Compounds 2018 http://www.lidsen.com/journals/genetics/genetics-02-03-029 Table 1 Screening results. Sirt activation is denoted by a minus sign. DNMT: DNA methylation transferase; SAM: S-adenosyl-methionine; SAH: S-Adenosyl-L-homocysteine; BRET: Bioluminescent resonance energy transfer; HDAC: Histone deacetylase; Sirt: Sirtuin; me3H3K9 and m..

2021 Complementary and alternative medicine (CAM) supplements in cancer outpatients: analyses of usage and of interaction risks with cancer treatment https://link.springer.com/article/10.1007/s00432-021-03675-7 표 4 기존 암 치료에 사용되는 CAM과 약물 간의 잠재적 상호 작용 비타민 비타민 A 가능: 간독성 효과. 시타 라빈, 다우 노루 비신, 독소루비신, 에피 루비 신, 젬시 타빈, 메토트렉세이트, 파클리탁셀, 토포 테칸, 트레티노인으로 간독성 등의 작용 약물 등으로 결합 할 때주의 가능:항산화 작용에 의한 안트라사이클린 및 기타 요법..

2016 https://www.sloankettering.edu/sites/default/files/node/12448/document/prashant_monian-final-thesis.pdf 그림 1.1. 포유류 세포에서 세포 사멸의 내인성 및 외인성 경로. 내인성 경로에서 세포 손상 신호는 BH3 전용 단백질을 통해 작용하여 Bax 및 Bak을 활성화하여 미토콘드리아 외막 투과화mitochondrial outer membrane permeabilization (MOMP)를 유도합니다. 그 결과 시토크롬 C(Cyt. C)가 방출되고 카스파제-9(C9)를 활성화하기 위한 구조인 apoptosome이 형성됩니다. Caspase-9는 이펙터 caspase-3 및 -7(C3/7)을 활성화합니다. MOMP는 ..