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Overcoming cancer therapeutic bottleneck by drug repurposing https://www.nature.com/articles/s41392-020-00213-8 Overcoming cancer therapeutic bottleneck by drug repurposing - Signal Transduction and Targeted Therapy www.nature.com 요약된 신호 네트워크에 의해 활성화된 약물 용도 변경을 사용하여 암세포의 특징을 표적으로 하는 약물 후보 식별. 암 세포의 특징에 기여하는 복잡한 신호 전달 상호 작용은 조정되어 신생물 질환의 복잡성을 합리화할 수 있습니다. 암 기능을 방해하는 약물 후보가 표시됩니다. Table 1 A total ..

Repurposing drugs in oncology: From candidate selection to clinical adoption https://www.sciencedirect.com/science/article/pii/S1044579X20300110 Repurposing drugs in oncology: From candidate selection to clinical adoption Drug repurposing is a strategy that aims to develop novel cancer treatments through the reuse of existing medicines developed in other disease areas. … www.sciencedirect.com Ta..

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer https://www.sciencedirect.com/science/article/pii/S1084952118301885 가능한 표적은 5개의 OXPHOS 복합체, 미토콘드리아 번역 및 미토콘드리아 생물발생을 포함 합니다. 워버그 효과 암세포 주로 에너지를 생성하는 상기 이상 설명 을 통해 충분한 산소가 존재하더라도 해당 작용한다. 종양이 에너지 생산을 위해 OXPHOS 대신 비효율적인 해당과정을 사용한다는 것은 역설처럼 보이지만 ATP 생성의 주요 경로가 암세포에서 재프로그래밍되는 이유에 대한 몇 가지 설명이 있습니다. 무엇보다도, 호기성 해당과정..

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096030/ https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4096024/ https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4720497/ https://www.ncbi.nlm.nih.gov/pmc/articles/pmc5102691/ https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4406527/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341996/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268104/ Table 1. The first s..

Small-molecule drug repurposing to target DNA damage repair and response pathways https://www.sciencedirect.com/science/article/pii/S1044579X20300468 Small-molecule drug repurposing to target DNA damage repair and response pathways For decades genotoxic therapy has been a mainstay in the treatment of cancer, based on the understanding that the deregulated growth and genomic insta… www.sciencedir..

Drug repurposing towards targeting cancer stem cells in pediatric brain tumors https://www.researchgate.net/profile/Hisham-Bahmad-2/publication/338492253_Drug_repurposing_towards_targeting_cancer_stem_cells_in_pediatric_brain_tumors/links/5ecf0845299bf1c67d23b956/Drug-repurposing-towards-targeting-cancer-stem-cells-in-pediatric-brain-tumors.pdf

An Alternative Pipeline for Glioblastoma Therapeutics: A Systematic Review of Drug Repurposing in Glioblastoma https://www.mdpi.com/2072-6694/13/8/1953/htm An Alternative Pipeline for Glioblastoma Therapeutics: A Systematic Review of Drug Repurposing in Glioblastoma The treatment of glioblastoma (GBM) remains a significant challenge, with outcome for most pa-tients remaining poor. Although novel..

https://synergiesforcancertreatments.blogspot.com/p/special-supplement-formulations.html Special Supplement Formulations? List of special supplement formulations (these either enhance the bioavailability, act as a prodrug, produce synergies, provide convenience... synergiesforcancertreatments.blogspot.com List of special supplement formulations (these either enhance the bioavailability, act as a..

https://synergiesforcancertreatments.blogspot.com/2020/11/combination-of-natural-supplements-as.html Combination of Natural Supplements as Adjunct Cancer Therapy Natural supplements can be very helpful adjuvant to drug therapies, for example through chemosensitization of tumor cells. Unfortunately, i... synergiesforcancertreatments.blogspot.com

https://synergiesforcancertreatments.blogspot.com/p/synergies.html Synergies ⚡ Synergy : two or more substances can be greater than the sum of their parts. (tip: Ctrl+F ⌨ to search this page) Garlic + Turmeric antic... synergiesforcancertreatments.blogspot.com Synergy: two or more substances can be greater than the sum of their parts. (tip: Ctrl+F ⌨ to search this page) Garlic + Turmeric anticho..