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https://www.ijpsonline.com/articles/an-update-on-the-role-of-nrf2-and-its-activators-in-diseases-associated-with-oxidative-stress.pdf An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress Nrf2 활성제가 Keap1이 Nrf2에 결합하는 것을 억제함으로써 Nrf2 전위를 안정화하고 촉진한다. Nrf2는 핵으로 전위될 때 OS와 염증을 감소시키는 항산화 및 항염증 물질의 생성을 유도합니다. Nrf2 활성화제의 몇 가지 예는 oleanolic acids (OAs), bardoxolone me..

https://www.mdpi.com/2072-6694/13/2/281/htm Nrf2의 탈당화는 FN3K에 의해 촉매되며, FN3K의 활성은 암세포가 악성 및 약물 내성 표현형으로 진행되는 동안 향상됩니다. 따라서 Nrf2의 탈당화는 부분적으로 암세포의 종양 발생 가능성에 기여할 수 있는 중요한 메커니즘 중 하나입니다. Table 2. Phytochemicals and drug interventions that modulate AGE-RAGE-mediated glycation to mitigate cancer cell growth. Phytochemical Signaling Pathways Cancers Refs Papavarine Downregulation of HMBG1, RAGE, and NF-κ..

https://www.mdpi.com/2072-6694/11/10/1618/htm A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and ep www.mdpi.com A Compreh..