열리라

https://www.sciencedirect.com/science/article/pii/S1535610819301977 Targeting Ferroptosis to Iron Out Cancer 2019 Table 1. Ferroptosis Stimuli MechanismTarget Compound/Drug Phenotype and Readout GPX4 inactivation due to GSH depletion (class I FINs) system XC− erastin lipid ROSa death inhibited by DFO, Fer1, and Trolox piperazine erastin increase in PTGS2 mRNA regression HT1080 xenografts imidazo..

https://www.frontiersin.org/articles/10.3389/fonc.2021.579286/full Ferroptosis: Biochemistry and Biology in Cancers The challenge of eradicating cancer is that cancer cells possess diverse mechanisms to protect themselves from clinical strategies. Recently, ferroptosis has been shown to exhibit appreciable anti-tumor activity that could be harnessed for cancer therapy i www.frontiersin.org Ferro..

https://onlinelibrary.wiley.com/doi/10.1111/cas.13537 NRF2 addiction in cancer cells The KEAP1-NRF2 system is a pivotal defense mechanism against oxidative and electrophilic stress. Cancer cells with persistent activation of NRF2 often develop “NRF2 addiction” and show malignant phen... onlinelibrary.wiley.com NRF2 addiction in cancer cells 2018 스트레스에 대한 일시적인 NRF2 활성화는 건강에 유익하지만 암세포에서 지속적인 NRF2 ..

https://www.mdpi.com/1420-3049/26/5/1417/htm Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer Cancer is one of the most fatal diseases with an increasing incidence and mortality all over the world. Thus, there is an urgent need for novel therapies targeting major cancer-related pathways. Nuclear factor-erythroid 2-related factor 2 (NRF2) and its ma www.mdpi.com NRF2(Nuclear factor-e..

https://www.hindawi.com/journals/omcl/2019/8592348/ Potential Applications of NRF2 Inhibitors in Cancer Therapy 2019 Potential Applications of NRF2 Inhibitors in Cancer Therapy The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Indeed, by increasing the expression of several cytoprotective genes, the transcription factor..

https://www.mdpi.com/1422-0067/20/8/2025/htm 2019 Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs Oxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most effective cytoprotective controller against OS. Modulation of Nrf2 pathway www.mdpi.c..

https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.2101 Nrf2 in cancers: A double-edged sword 2019 Nrf2 in cancers: A double‐edged sword The Nrf2/Keap1 pathway is an important signaling cascade responsible for the resistance of oxidative damage induced by exogenous chemicals. However, the constitutive activation of Nrf2 in various can... onlinelibrary.wiley.com 암세포에서 Nrf2의 종양형성 촉진 역할이 명확하게 밝혀..

https://www.researchgate.net/profile/Jing-Liu-301/publication/230826630_Recent_Agents_Targeting_HIF-1_alpha_for_Cancer_Therapy/links/5a9de059a6fdccff6d1a1b3f/Recent-Agents-Targeting-HIF-1-alpha-for-Cancer-Therapy.pdf 2012 Recent Agents Targeting HIF-1a for Cancer Therapy Silibinin EGCG Resveratrol *****************************************

https://dipbsf.uninsubria.it/monti/BFPN%202010/Biblio%20BFPN%202010/BFPN%20HIF1/HIF%20Semenza%202003.pdf TARGETING HIF-1 FOR CANCER THERAPY HIF-1α의 경우 합성은 O2-독립적 기전을 통해 조절되는 반면(도 1), 분해는 주로 O2-의존적 기전을 통해 조절되며(도 2), 아래에서 설명합니다. Summary .저산소증 유발성 인자 1(HIF-1)은 두 개의 단백질로 구성된 이종이량체 단백질입니다. HIF-1α 및 HIF-1β.HIF-1은 혈관신생, 포도당 대사, 세포 증식/생존 및 침습/전이에 관여하는 단백질을 암호화하는 많은 유전자의 전사를 활성화합니다. .HIF-1α 단백질 합성은 포스파티딜..

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559821/ The Transcriptional Factors HIF-1 and HIF-2 and Their Novel Inhibitors in Cancer Therapy 2019 소개: 저산소증은 고형 종양의 본질적인 특징 중 하나이며 방사선 및 화학 요법에 대한 내성, 전이 및 불량한 환자 예후를 포함하여 항상 공격적인 표현형과 관련이 있습니다. 저산소증은 전사 인자 계열의 활성화를 통해 이러한 불리한 효과를 나타냅니다. 저산소증 유도 인자(HIF)는 여러 pro-oncogenic 유전자의 전사를 상향 조절함으로써 종양 세포가 저산소 상태 및 영양 결핍 조건에 적응하는 데 중추적인 역할을 합니다. 여러 진행성 인간 암..